Toxicity Data for Phthalate Plasticizers

Phthalate Plasticizers
PlasticizersAcute toxicity
Chronic Toxicity
84617Dicyclohexyl phthalate YNYNN
84662Diethyl phthalateYNYYY
84695Diisobutyl phthalateYNYYY
84742Dibutyl PhthalateYYYYY
84775Dodecyl phthalateYNNNN
85687Dibutyl benzyl phthalateYYYYY
85698Dibutyldioctyl phthalateNNNNY
117817Di(2-ethylhexyl) phthalateYYYYY
117840Dioctyl phthalateYNYYY
119062Bis(tridecyl) phthalateYNNYY
131113Dimethyl phthalateYYYYY
131179Diallyl phthalateYNNYY
26761400Diisodecyl phthalateYYYYY
28553120Di-isononyl phthalateNNNNN
Note: Y – yes; N – no.

DOP (Di (2-ethylhexyl) phthalate) has always been the first choice of PVC plasticizers because of its high plasticizing efficiency, low volatility, low migration, excellent flexibility and electrical properties, and has an irreplaceable importance in the PVC processing industry. But with the DOP in the food and pharmaceutical industry more widely used, people are paying more and more attention to its toxicity.

It has been found that phthalates can cause the so-called pulmonary shock phenomenon, the United States in the Vietnam War, it was found that the use of PVC transfusion bags after long-term blood preservation, the wounded suffered breathing difficulties, and in serious cases can also lead to death.

In 1982, the National Cancer Institute conducted a biological evaluation of the carcinogenicity of DOP and concluded that DOP is a carcinogen in rats and mice and can cause cancer in the liver of rodents. As a result, global attention was drawn to the toxicity of DOP. Although whether it is carcinogenic to humans is still a matter of debate, countries have taken appropriate measures due to its potential carcinogenic suspects.

With recent health concerns and advances in research on traditional PVC phthalate plasticizers, the toxicity of phthalate plasticizers such as DOP has been better understood. The release of DOP from PVC medical devices into the body poses a greater risk to patients, especially children and pregnant women in the early developmental and differentiationally sensitive stages.

In 2005, researchers at the University of Ergen, Germany, found that DOP is much more harmful than expected. Animal studies conducted by the researchers showed that the substance affects the human hormone system, especially in growing adolescents, and is detrimental to testicular growth and development in boys. For this reason, DOP is classified as a reproductive toxin and labeled as toxic by the European Union.

In 2002, a Swedish laboratory reported that DEHP in cosmetics can enter women’s bodies through their respiratory system and skin, and may affect the reproductive health of their baby boys. As a result, many organizations have banned the use of DEHP and other phthalates in cosmetics. However, the European Association for Cosmetics, Toiletries and Fragrances (EACF) considers the report inaccurate and misleading.

In February 2004, the Knight-Ridder study showed that phthalate chemicals pose a medical risk.

In July 2005, the Harvard study showed that infants are exposed to phthalates through objects.

A team of researchers in a Swedish-Danish collaboration also found that certain varieties of phthalates, DEHP and BBzP, are somehow causally associated with allergy symptoms and asthma in children in long-term studies.

Preferred PETS for PVC Plasticizers

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